Osimert 80 mg Osimertinib
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| Picture of Osimert 80 mg Tablet |
Osimert 80mg is a cancer treatment drug that is commonly prescribed in the treatment of lung cancer.
Active ingredient name: Osimertinib mesylate 80mg
Brand name: Osimert 80mg
Dosage form: 1 bottle x 30 tablets.
What is Osimert?
Osimert 80mg is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) developed by AstraZeneca. It is a targeted cancer treatment that works by blocking the activity of an abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells and helps shrink tumors.
Indications of Osimert 80mg are approved by the FDA and approved for use in the following cases:
Adjuvant therapy after surgical resection in adult patients with NSCLC and tumors with epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 L858R mutation (as detected by an FDA-approved test)
First-line treatment of adult patients with locally advanced or metastatic NSCLC with epidermal growth factor receptor EGFR exon 19 deletion or exon 21 L858R mutation (as detected by an FDA-approved test).
Treatment of adult patients with locally advanced or metastatic EGFR T790M mutation-positive NSCLC, as detected by an FDA-approved test, and whose disease has progressed during or following first-line treatment with an EGFR-TKI.
Osimert 80mg is usually given after other treatments have failed.
Approximately 10% of patients with NSCLC have a rapid and effective clinical response to EGFR-TKI.
The development of third-generation EGFR-TKIs such as Osimert is in response to the changing tumor resistance mechanisms after treatment and to reduce toxic side effects that affect patients' quality of life.
Some other uses of this drug are not listed in the approved labeling for the drug but may be prescribed by your doctor. Use this drug to treat certain conditions only as directed by your doctor.
What forms and strengths does Osimert 80mg come in?
The drug is in tablet form, each tablet contains the active ingredient Osimertinib (as Osimertinib mesylate) 80mg, packaged in a box of 30 tablets.
What is the dosage of Osimert 80mg for adults?
Treatment with Osimert should be initiated by a physician experienced in the use of anticancer therapies.
The usual dose for adults with non-small cell lung cancer is one tablet taken once daily.
How should you take Osimert 80mg?
The medication is taken by mouth and should be taken at the same time each day. Osimert can be taken with or without food. Take it with a full glass of water.
If the patient has difficulty swallowing, you can dissolve the medicine in water. Put 4 tablespoons of water (about 60ml) into a cup, then add the medicine and stir until the tablet is dissolved, then drink the mixture immediately. Add a little water to the cup to rinse the remaining medicine in the cup, swirl gently and drink to ensure the full dose of medicine is received.
Note: Do not use carbonated water or any other liquid to dissolve the tablet. Do not crush the tablet or heat the medication mixture.
The medication can also be administered through a nasogastric tube. Dissolve the tablet in 15ml of water, then add another 15ml of water to transfer the medication into the tube.
You should use Osimert while it is still effective and without too many side effects. The length of treatment depends on how effective the drug is and the side effects you experience.
If you take Osimert after surgery, you will take it for up to 3 years.
Take this medication exactly as directed on the label and follow the directions and instructions of your doctor. Do not take more or less of it or take it more often than prescribed by your doctor.
Be sure to talk to your doctor during treatment. Do not stop taking your medication without consulting your doctor.
What should you do in case of overdose?
In case of emergency or overdose, call 115 Emergency Center immediately or go to the nearest local health station.
In addition, you should write down and bring a list of medications you take, including prescription and non-prescription drugs.
What should you do if you miss a dose?
If you miss a dose, take it as soon as possible. However, if it is close to the time for your next dose (within 12 hours), skip the missed dose and take your next dose at the regular time. Do not double the dose.
Side effects
What side effects will you experience when taking Osimert 80mg?
Common side effects of Osimert 80mg include:
Increased risk of infection: fever, muscle aches, headache, feeling cold, shivering and tired
Bruising, bleeding gums or nosebleeds
Diarrhea
Skin problems include skin rashes, dry skin and itching
Mouth ulcers
Anorexia
Stomach-ache
Nausea, vomiting
Back-ache
Headache
Pain, discoloration, infection, or other problems with fingernails or toenails.
Rare side effects:
Hives
Increased blood creatinine levels
Thinning hair or complete hair loss
Inflammation and scarring of lung tissue causing difficulty breathing, coughing or high fever
Redness and peeling of the hands and feet (called hand-foot syndrome or plantar fasciitis)
Swelling of the face, lips, tongue, or throat.
Call your doctor right away if you notice the following rare side effects:
Rash, blistering or peeling of the skin.
Heart problems such as changes in heart function (QTc prolongation) or heart failure causing shortness of breath, rapid or pounding heartbeat, chest pain, etc.
Keratitis causes eye pain, watery eyes, sensitivity to light, blurred vision, and red eyes.
Cutaneous vasculitis causes bruises or skin rashes on the arms, legs, buttocks, or all over the body.
Nail problems, including swelling around the nail, brittle nails, dryness, pain, discoloration, or ridges. The skin around the nail becomes swollen, red, painful, or infected.
Swelling of the ankles or feet.
Feels like I might pass out.
Persistent fever, bruising or bleeding, pale skin, unusual tiredness or weakness, or any other signs of infection.
Osimert 80mg can cause serious side effects to your heart, lungs, or vision. Call your doctor right away if you have any of these signs.
Your doctor may ask you to stop treatment temporarily or permanently or reduce the dose of the medication depending on the side effects you experience.
This is not a complete list of side effects and others may occur. If you have any questions about side effects, consult your doctor or pharmacist.
Caution/Warning
Before taking Osimert 80mg, what should you note?
Osimert 80mg is contraindicated if you are allergic to any ingredient of the drug.
Osimert should not be used with St. John's Wort.
When using the drug, regular blood tests are required before and during treatment, as well as checking liver, kidney and heart function.
The medicine can reduce fertility in both men and women. However, you should not assume that you or your partner cannot get pregnant. Tell your doctor before treatment if you are pregnant, or are planning to become pregnant. You will need to have a pregnancy test before starting treatment and should not become pregnant while taking the medicine.
If you are a woman, use effective birth control during treatment with Osimert and for at least 2 months after your last dose. If you are a man and your partner is able to get pregnant, use effective birth control during treatment and for at least 4 months after your last dose. Talk to your doctor about suitable birth control methods. If you become pregnant while taking this medicine, call your doctor immediately.
Things you need to keep in mind when taking medicine in special cases (pregnancy, breastfeeding, surgery, etc.)
Do not use Osimert 80mg for pregnant women because the drug can harm the fetus.
Breastfeeding women should also not use Osimert 80mg or if used, should stop breastfeeding during treatment and for at least 2 weeks after the last dose.
Drug interactions
What drugs can interact with Osimert 80mg?
Osimert may change the way other medications you are taking work or increase the risk of side effects. To avoid drug interactions, it is best to keep a list of all the medications you are taking (including prescription, nonprescription, herbal, and dietary supplements) and show it to your doctor or pharmacist. To ensure safety when taking medication, do not start, stop, or change the dosage of any medication without your doctor's approval.
Osimert should not be used with any of the following medications:
Abametapir
Abatacept
Abemaciclib
Abrocitinib
Acalabrutinib
Acenocoumarol
Acetazolamide
Acyclovir
Adagrasib
What foods and drinks should I avoid while taking this medication?
Unless your doctor gives you specific instructions, continue your normal diet.
When taking medication, in addition to following the doctor's instructions, you should limit the use of processed foods high in fat and preservatives. In addition, you should also avoid carbonated drinks and foods containing alcohol and stimulants such as wine, beer, cigarettes, etc.
Food, alcohol, and tobacco can interact with certain medications. Talk to your doctor about taking your medication with food, alcohol, and tobacco.
What health conditions affect the medication?
Your medical condition may affect the use of this medicine. Tell your doctor if you have any medical problems.
Tell your doctor if you have ever had:
QT prolongation (a condition that increases the risk of developing an irregular heartbeat that can cause fainting or sudden death)
Irregular heartbeat
Heart failure (a condition in which the heart cannot pump enough blood to other parts of the body)
High blood pressure
Blood levels of sodium, potassium, calcium, or magnesium that are higher or lower than normal
Eye problems
Other lung diseases.
Drug storage
How should you store Osimert 80mg?
Store at room temperature, away from moisture and light. Do not store in the bathroom or freezer. Remember that different medications may require different storage methods. Therefore, you should read the storage instructions on the package carefully or ask your pharmacist. Keep medications out of the reach of children and pets.
Where to buy, price
How much does Osimert 80mg cost and where to buy it?
If you are wondering where to buy Osimert 80mg, the answer is that you can buy Osimert at some major pharmacies and reputable hospitals nationwide. In addition, you can also order online on e-commerce sites and reputable online pharmacies.
How much does Osimert 80mg cost?
Osimert 80 mg price in Bangladesh is about $180 but the price can be changed on time. And the osimert price may vary on location and quantity. To know the exact price of osimert feel free to contact us. You may also check the price of osimert in India here.
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